The Science Behind ENHANCE

Sentientz science-based fuel for the brain. Fully backed science on each ingredient showing the long-term positive effect on brain function and health. Feed your brain for improved memory, alertness and focus on everyday activities and excel at every level with some of the cleanest and most effective cognition-enhancing ingredients available today.

St. John’s Wort

St. John’s wort is a yellow, flowering plant native to Europe and the United States.

It has been used for a variety of therapeutic purposes in the Mediterranean for millennia and has been widely studied and used clinically in Europe for decades. Multiple clinical studies have demonstrated St. John’s wort is almost as effective as a prescription antidepressant for reducing sadness, anxiety, and feelings of hopelessness.

Additionally, the medicine appears to ease many of the symptoms that often accompany depression, such as sleeplessness and poor appetite. The key ingredient is believed to be hyperforin, a phytochemical (plant-produced chemical), which may act upon the presynaptic nerves in the brain to build up serotonin levels, much like a selective serotonin reuptake inhibitor would.

The exact mechanism of hyperforin hasn’t been definitively identified, but there is enough positive data to declare St. John’s wort an effective antidepressant therapy. Hyperforin has a short half-life, so St. John’s wort should be taken at the recommended dosage three times daily.

References:

St. John’s wort for treating depression.

A systematic review of St. John’s wort for major depressive disorder.

Clinical Use of Hypericum Perforatum (St John’s Wort) in Depression: A Meta-Analysis.

Glutamine (as L-glutamine hydrochloride)

Glutamine’s immune system benefits are related to its role in intestinal health. In the human body, the intestines are considered the largest portion of the immune system. This is because of the many intestinal cells with immune functions, as well as the trillions of bacteria that live in your intestines and impact your immune health.

Glutamine is an important energy source for intestinal and immune cells. It also helps maintain the barrier between the inside of your intestines and the rest of your body, thereby protecting against a leaky gut. This prevents harmful bacteria or toxins from moving from your intestines into the rest of your body.

Additionally, it is important for the normal growth and maintenance of the cells in the intestine.

Due to the major role of the intestines in the immune system, glutamine may benefit your overall immune health by supporting the intestinal cells.

References:

Glutamine and the Immune System.

Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions.

Glutamine and Intestinal Barrier Function.

Phosphatidylserine Complex

Commonly used for improving thinking skills in young people, attention deficit-hyperactivity disorder (ADHD), depression, preventing exercise-induced stress, and improving athletic performance.

Phosphatidylserine improves attention, language skills, and memory in aging people with declining thinking skills. There is developing evidence that plant-derived phosphatidylserine improves memory in people with age-associated memory loss.

Figure 1 - A significant improvement in sustained attention and memory recognition was observed in the PS-DHA naïve group, while the PS-DHA continuers maintained their cognitive status. A significant improvement in CGI-C was observed in the naïve group

References:

Phosphatidylserine and the human brain.

Effects of Phosphatidylserine Supplementation on Exercising Humans.

The effect of phosphatidylserine administration on memory and symptoms of attention‐deficit hyperactivity disorder: a randomised, double‐blind, placebo‐controlled clinical trial.

Bacopa monnieri

Bacopa monnieri is an ancient Ayurvedic herbal remedy for many ailments.

Human studies show it may help boost brain function, treat ADHD symptoms, and reduce stress and anxiety. Furthermore, test-tube and animal studies have found that it may possess anticancer properties and reduce inflammation and blood pressure.

Figure 2 - Effect of standardized Bacopa monnieri extract (Bacognize ® ) on different components of Mini Mental State Examination Scale (MMSES) (n= 39)

References:

Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain.

Neuroprotective Effects of Bacopa Monnieri in Experimental Model of Dementia.

A Review on the Antioxidant and Therapeutic Potential of Bacopa monnieri.

DMAE Bitartrate

DMAE Bitartrate, which is sometimes referred to as Deanol, is an antioxidant that helps nerve cells send signals to the brain. It occurs naturally, known to be similar to Choline on a purely chemical basis working closely with the vitamin B chain.

Physically, it is a precursor to getting rid of the excess fat which tends to accumulate in the liver and improve aging skin. In addition to this, the chemical improves neurotransmission to the brain, improving memory as well as positively affecting mood.

References:

New Insights on Dimethylaminoethanol (DMAE) Features as a Free Radical Scavenger.

DMAE as sole agent for the treatment of mild cognitive impairment.

N-Acetyl-L-Carnitine HCI

L-carnitine is an amino acid (a building block for proteins). It helps produce energy and boost your metabolism rates.

In the body, acetyl-L-carnitine is made from L-carnitine. It supports your healthy blood lipids and cardiovascular strength to maintain your energy and alertness levels.

Acetyl-L-carnitine can support a variety of mental conditions including Alzheimer's disease, age-related memory loss, bipolar disorder, and late-life depression. It is also used for withdrawal from alcohol, and addictive activities.

Figure 3 LAC supplementation induces rapid and lasting epigenetic antidepressant-like effects via acetylation of histones.

References:

Acetyl-l-carnitine deficiency in patients with major depressive disorder.

Physiological Functions of Carnitine and Carnitine Transporters in the Central Nervous System.

Mental Impairment in Aging: Selection of Patients, Methods of Evaluation and Therapeutic Possibilities of acetyl-L-carnitine.

Ginkgo biloba

Ginkgo supplements are associated with several health claims and uses, most of which focus on brain function and blood circulation.

While its leaves and seeds are often used in traditional Chinese medicine, modern research primarily focuses on ginkgo extract, which is made from the leaves.

Ginkgo biloba has strong anti-inflammatory and antioxidant capacities and an ability to improve circulation.

References:

Effects of Ginkgo biloba extract EGb 761® on cognitive control functions, mental activity of the prefrontal cortex and stress reactivity in elderly adults with subjective memory impairment – a randomized double‐blind placebo‐controlled trial.

Advances in the Studies of Ginkgo Biloba Leaves Extract on Aging-Related Diseases.

AA Double-Blind, Placebo-Controlled, Randomized Trial of Ginkgo Biloba Extract EGb 761 in a Sample of Cognitively Intact Older Adults: Neuropsychological Findings.

Huperzine-A

Huperzine A is a substance purified from a plant called Chinese club moss, and is used for Alzheimer's disease, memory and learning enhancement, and age-related memory impairment. It is also used for treating a muscle disease called myasthenia gravis, for increasing alertness and energy, and for protecting against agents that damage the nerves such as nerve gases.

References:

Huperzine-A Capsules Enhance Memory and Learning Performance in 34 Pairs of Matched Adolescent Students.

Huperzine A for Alzheimer's disease.

Efficacy of Tablet huperzine-A on Memory, Cognition, and Behavior in Alzheimer's Disease.

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